Rank Ligand : The skeleton is the most common site affected by metastases1,2

The skeleton is the most common site affected by metastases1,2
Incidence of SREs in patients with cancer
Frequency of subsequent SREs
Bone pain is the most common complication of metastatic bone disease1

Get to know the KEY PLAYERS in the vicious
cycle of metastatic bone destruction.

The incidence and impact of bone metastases and skeletal-related events (SREs).

The skeleton is the most common site affected by metastases1,2

Incidence of bone metastases among common cancer types

- Cancer type
- Breast
- Prostate
- Multiple myeloma
- Lung
- Kidney
- Thyroid
- Melanoma
- Incidence of bone metastases or lesions (%)
- 65–75
- 65–75
- 95–100
- 30–40
- 20–25
- 60
- 14–45
Adapted from Coleman, 1997 and Rubens 1995.1,2

As shown above, in advanced prostate cancer and breast cancer, 65–75% of patients may eventually develop bone metastases.3 It is also important to note that approximately 10% of men with prostate cancer have bone metastases at initial presentation. Almost all patients who die of prostate cancer have bone involvement.3